Which antibiotic is associated with the chemical structure Rifampicin?

Which antibiotic is associated with the chemical structure Rifampicin?

• A. Ofloxacin
• B. Minocycline
• C. Rifampicin
• D. Amoxicillin

Answer: (C)

This item hinges on recognizing the distinctive scaffold of the rifamycin family. Rifampicin is the antibiotic tied to that structure because rifampicins possess a large macrocyclic core (the ansa-bridge linked to a naphthoquinone-containing ring) that sets them apart from other antibiotic classes. This rifamycin-style structure is unique among common antibiotics: Ofloxacin has a fluoroquinolone core, minocycline is built on a tetracycline four-ring system, and amoxicillin contains a beta-lactam ring fused to a thiazolidine moiety. The structure shown is the hallmark rifampicin, the representative member of that class.

This item hinges on recognizing the distinctive scaffold of the rifamycin family. Rifampicin is the antibiotic tied to that structure because rifampicins possess a large macrocyclic core (the ansa-bridge linked to a naphthoquinone-containing ring) that sets them apart from other antibiotic classes. This rifamycin-style structure is unique among common antibiotics: Ofloxacin has a fluoroquinolone core, minocycline is built on a tetracycline four-ring system, and amoxicillin contains a beta-lactam ring fused to a thiazolidine moiety. The structure shown is the hallmark rifampicin, the representative member of that class.